MESA regularly reviews scientific literature related to the ingredients used in its products, and shares that review here. Our aim is to present relevant research responsibly and transparently.
All Research
How to read this library
01Evidence level describes the strength of the available published research.
02Formulation relevance describes how closely that research matches the ingredient's actual use in MESA products.
03Scientific literature provides context and does not automatically establish efficacy or clinical claims for MESA's finished products.
Scientific publications presented here concern individual ingredients or related preparations and should not be interpreted as clinical evidence for the finished MESA product unless explicitly stated.
Systematic Review · 2020
Ginger on Human Health: A Comprehensive Systematic Review of 109 Randomized Controlled Trials
Anh NH, Kim SJ, Long NP, Min JE, Yoon YC, Lee EG, Kim M, Kim TJ, Yang YY, Son EY, Yoon SJ, Diem NC, Kim HM, Kwon SW — Nutrients
The clinical effects of orally consumed ginger (Zingiber officinale) across every health area reported in the RCT literature, from nausea and inflammation to metabolic and digestive outcomes.
Evidence Level
Limited
Formulation Relevance
Indirect
Indirect relevance means the available research is related to the ingredient or a similar use, but does not directly evaluate MESA's finished product or its exact formulation.
Efficacy and tolerability of a spray with Salvia officinalis in the treatment of acute pharyngitis — a randomised, double-blind, placebo-controlled study with adaptive design and interim analysis
Hubbert M, Sievers H, Lehnfeld R, Kehrl W — European Journal of Medical Research
Whether a spray containing Salvia officinalis (sage) extract relieves the symptoms of acute pharyngitis (sore throat) compared to placebo.
Evidence Level
Moderate
Formulation Relevance
Related
The available research is relevant to the ingredient or a comparable application, but it still does not constitute clinical evidence for the finished MESA product.
Echinacea for preventing and treating the common cold
Karsch-Völk M, Barrett B, Kiefer D, Bauer R, Ardjomand-Woelkart K, Linde K — Cochrane Database of Systematic Reviews
Whether Echinacea preparations prevent or treat the common cold, compared to placebo.
Evidence Level
Limited
Formulation Relevance
Indirect
Indirect relevance means the available research is related to the ingredient or a similar use, but does not directly evaluate MESA's finished product or its exact formulation.
Topical application of licorice for prevention of postoperative sore throat in adults: A systematic review and meta-analysis
Kuriyama A, Maeda H — Journal of Clinical Anesthesia
Whether a topical licorice gargle, used before surgery, prevents sore throat caused by tracheal intubation.
Evidence Level
Moderate
Formulation Relevance
Indirect
Indirect relevance means the available research is related to the ingredient or a similar use, but does not directly evaluate MESA's finished product or its exact formulation.
Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review
Nazari S, Rameshrad M, Hosseinzadeh H — Phytotherapy Research
The toxicological and adverse-effect profile of licorice (Glycyrrhiza glabra) and its main constituent glycyrrhizin, across the available literature.
Evidence Level
Moderate
Formulation Relevance
Related
The available research is relevant to the ingredient or a comparable application, but it still does not constitute clinical evidence for the finished MESA product.
The Potential Use of Propolis as a Primary or an Adjunctive Therapy in Respiratory Tract-Related Diseases and Disorders: A Systematic Scoping Review
Zulhendri F, Perera CO, Tandean S, Abdulah R, Herman H, Christoper A, et al. — Biomedicine & Pharmacotherapy
Whether propolis has therapeutic value, as a primary or adjunctive treatment, across respiratory tract-related diseases and disorders.
Evidence Level
Limited
Formulation Relevance
Indirect
Indirect relevance means the available research is related to the ingredient or a similar use, but does not directly evaluate MESA's finished product or its exact formulation.
Pelargonium sidoides for acute bronchitis: A systematic review and meta-analysis
Agbabiaka TB, Guo R, Ernst E — Phytomedicine
Whether a standardized Pelargonium sidoides root extract (EPs 7630) is effective for treating acute bronchitis.
Evidence Level
Moderate
Formulation Relevance
Indirect
Indirect relevance means the available research is related to the ingredient or a similar use, but does not directly evaluate MESA's finished product or its exact formulation.
Efficacy and Safety of Eucalyptus for Relieving Cough: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Her L, Kanjanasilp J, Chaiyakunapruk N, Sawangjit R — Journal of Integrative and Complementary Medicine
Whether Eucalyptus-containing products relieve cough compared to placebo.
Evidence Level
Limited
Formulation Relevance
Related
The available research is relevant to the ingredient or a comparable application, but it still does not constitute clinical evidence for the finished MESA product.
Zinc for prevention and treatment of the common cold
Nault D, Machingo TA, Shipper AG, Antiporta DA, Hamel C, Nourouzpour S, Konstantinidis M, Phillips E, Lipski EA, Wieland LS — Cochrane Database of Systematic Reviews
Whether zinc supplements prevent or shorten the common cold compared to placebo.
Evidence Level
Limited
Formulation Relevance
Related
The available research is relevant to the ingredient or a comparable application, but it still does not constitute clinical evidence for the finished MESA product.
Vitamin C for preventing and treating the common cold
Hemilä H, Chalker E — Cochrane Database of Systematic Reviews
Whether regular or therapeutic vitamin C supplementation prevents or shortens the common cold.
Evidence Level
Moderate
Formulation Relevance
Related
The available research is relevant to the ingredient or a comparable application, but it still does not constitute clinical evidence for the finished MESA product.
Clinical and Preclinical Systematic Review of Panax ginseng C. A. Mey and Its Compounds for Fatigue
Jin TY, Rong PQ, Liang HY, Zhang PP, Zheng GQ, Lin Y — Frontiers in Pharmacology
Whether Panax ginseng C.A. Mey. and its compounds reduce fatigue, in both human clinical trials and animal models.
Evidence Level
Moderate
Formulation Relevance
Indirect
Indirect relevance means the available research is related to the ingredient or a similar use, but does not directly evaluate MESA's finished product or its exact formulation.
The available research is relevant to the ingredient or a comparable application, but it still does not constitute clinical evidence for the finished MESA product.
Antifungal climbazole alters androgenic pathways in mammalian cells
Ndiaye D, Perceau M, Lorcin M, Denis F, Gaté L — Toxicology in Vitro
Whether climbazole, an antifungal used in anti-dandruff shampoos, disrupts hormone (androgen/estrogen) pathways in cell-culture models.
Evidence Level
Preliminary
Formulation Relevance
Related
The available research is relevant to the ingredient or a comparable application, but it still does not constitute clinical evidence for the finished MESA product.
Efficacy of a piroctone olamine/climbazol shampoo in comparison with a zinc pyrithione shampoo in subjects with moderate to severe dandruff
Schmidt-Rose T, Braren S, Fölster H, Hillemann T, Oltrogge B, Philipp P, Weets G, Fey S — International Journal of Cosmetic Science
Whether a shampoo combining piroctone olamine and climbazole is as effective against dandruff as a standard zinc pyrithione shampoo.
Evidence Level
Moderate
Formulation Relevance
Related
The available research is relevant to the ingredient or a comparable application, but it still does not constitute clinical evidence for the finished MESA product.
Scalp application of the antioxidant piroctone olamine reduces hair shedding in an 8-week randomized, double-blind, placebo-controlled clinical study
Davis MG, Piliang MP, Bergfeld WF, Caterino TL, Fisher BK, Sacha JP, Carr GJ, Moulton LT, Whittenbarger DJ, Punyani S, Schwartz JR — International Journal of Cosmetic Science
Whether scalp application of piroctone olamine reduces hair shedding in people with self-perceived hair thinning.
Evidence Level
Moderate
Formulation Relevance
Related
The available research is relevant to the ingredient or a comparable application, but it still does not constitute clinical evidence for the finished MESA product.
Urtica dioica extract downregulates the gene expression of 5α-RII in HaCaT cells: possible implications against androgenic skin diseases
Pekmezci E, Turkoglu M — Georgian Medical News
Whether an extract of Urtica dioica (nettle) can suppress the gene for 5α-reductase type II, an enzyme implicated in androgen-driven hair loss, in a skin-cell model.
Evidence Level
Preliminary
Formulation Relevance
Indirect
Indirect relevance means the available research is related to the ingredient or a similar use, but does not directly evaluate MESA's finished product or its exact formulation.
