MESA regularly reviews scientific literature related to the ingredients used in its products, and shares that review here. Our aim is to present relevant research responsibly and transparently.
All Research
How to read this library
01Evidence level describes the strength of the available published research.
02Formulation relevance describes how closely that research matches the ingredient's actual use in MESA products.
03Scientific literature provides context and does not automatically establish efficacy or clinical claims for MESA's finished products.
Scientific publications presented here concern individual ingredients or related preparations and should not be interpreted as clinical evidence for the finished MESA product unless explicitly stated.
SEOXIN
All Hair Types Anti Hair Loss Shampoo
Scientific Literature
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Why is this ingredient used?
An ingredient may be included based on its established use, known properties, formulation purpose, or broader scientific interest even when clinical evidence for a specific outcome remains limited. The evidence level shown here describes the strength of the published evidence for the research question reviewed — it does not mean that the ingredient has no known properties or that its use in a formulation is scientifically meaningless.
What the evidence means
Evidence levels describe the strength and relevance of the available scientific literature. They should not be interpreted as a rating of the ingredient itself or as a direct clinical claim about MESA products.
Systematic Review · 2020
Clinical and Preclinical Systematic Review of Panax ginseng C. A. Mey and Its Compounds for Fatigue
Jin TY, Rong PQ, Liang HY, Zhang PP, Zheng GQ, Lin Y — Frontiers in Pharmacology
Whether Panax ginseng C.A. Mey. and its compounds reduce fatigue, in both human clinical trials and animal models.
Evidence Level
Moderate
Formulation Relevance
Indirect
Indirect relevance means the available research is related to the ingredient or a similar use, but does not directly evaluate MESA's finished product or its exact formulation.
The available research is relevant to the ingredient or a comparable application, but it still does not constitute clinical evidence for the finished MESA product.
Antifungal climbazole alters androgenic pathways in mammalian cells
Ndiaye D, Perceau M, Lorcin M, Denis F, Gaté L — Toxicology in Vitro
Whether climbazole, an antifungal used in anti-dandruff shampoos, disrupts hormone (androgen/estrogen) pathways in cell-culture models.
Evidence Level
Preliminary
Formulation Relevance
Related
The available research is relevant to the ingredient or a comparable application, but it still does not constitute clinical evidence for the finished MESA product.
Efficacy of a piroctone olamine/climbazol shampoo in comparison with a zinc pyrithione shampoo in subjects with moderate to severe dandruff
Schmidt-Rose T, Braren S, Fölster H, Hillemann T, Oltrogge B, Philipp P, Weets G, Fey S — International Journal of Cosmetic Science
Whether a shampoo combining piroctone olamine and climbazole is as effective against dandruff as a standard zinc pyrithione shampoo.
Evidence Level
Moderate
Formulation Relevance
Related
The available research is relevant to the ingredient or a comparable application, but it still does not constitute clinical evidence for the finished MESA product.
Scalp application of the antioxidant piroctone olamine reduces hair shedding in an 8-week randomized, double-blind, placebo-controlled clinical study
Davis MG, Piliang MP, Bergfeld WF, Caterino TL, Fisher BK, Sacha JP, Carr GJ, Moulton LT, Whittenbarger DJ, Punyani S, Schwartz JR — International Journal of Cosmetic Science
Whether scalp application of piroctone olamine reduces hair shedding in people with self-perceived hair thinning.
Evidence Level
Moderate
Formulation Relevance
Related
The available research is relevant to the ingredient or a comparable application, but it still does not constitute clinical evidence for the finished MESA product.
Urtica dioica extract downregulates the gene expression of 5α-RII in HaCaT cells: possible implications against androgenic skin diseases
Pekmezci E, Turkoglu M — Georgian Medical News
Whether an extract of Urtica dioica (nettle) can suppress the gene for 5α-reductase type II, an enzyme implicated in androgen-driven hair loss, in a skin-cell model.
Evidence Level
Preliminary
Formulation Relevance
Indirect
Indirect relevance means the available research is related to the ingredient or a similar use, but does not directly evaluate MESA's finished product or its exact formulation.
